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:: Volume 4, Issue 2 (7-2015) ::
wjps 2015, 4(2): 134-144 Back to browse issues page
The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat
Ebrahim Nasiri , Seyed Jalal Hosseinimehr , Mohammad Azadbakht , Jafar Akbari , Reza Enayati-Fard , Sohail Azizi , Masoud Azadbakht
Abstract:   (4038 Views)
Background Burn is still a majordevastating condition in emergency medicine departments among both genders and all age groups in all developed and developing countries, leading to physical, psychological scars and economical burden. The present study aimed to determine the healing effect of topical treatment with Arnebia euchroma on second-degree burn wound in rats. Methods Fifty rats were divided into 4 equal groups receiving the ointment base, normal saline (NS), standard 1% silver sulfadiazine (SSD), and 5% and 10% Arnebia euchroma ointments (AEO). The mean of burn area, percentage of wound contraction, histopathological and bacteriological assessments in the injured area were dtermined during the study. Results Average area of wound on the 10th day was 10.2±2.3, 8.4±2.6, 12.4±2.5, 5.9±2.2 and 5.7±2 cm2 for ointment base, NS, 1% SSD, and 5% and 10% AEO, respectively. Wound size was significantly lower in 10% AEO than 1% SSD and control groups on the 10th day post-burn injury. On day 11, the percentage of wound contraction in 5% and 10% AEO was 53.9%±14.7% and 55.9±10.5% which was more than 1% SSD (15.3±10.8%). The collagen fibers were well formed and horizontally-oriented in 5% and 10% AEO groups when compared with other groups. Conclusion Arnebia euchroma ointment was an effective treatment for healing of burn wounds in comparison with SSD and can be regarded as an alternative topical treatment for burn wounds.
Keywords: Arnebia euchroma, Burns, Silver sulfadiazine, Rat, Wound healing
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Type of Study: Original Article | Subject: General
Received: 2015/01/5 | Accepted: 2015/04/21 | Published: 2015/04/21
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Nasiri E, Hosseinimehr S J, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S et al . The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat. wjps. 2015; 4 (2) :134-144
URL: http://wjps.ir/article-1-140-en.html

Volume 4, Issue 2 (7-2015) Back to browse issues page
مجله جهانی جراحی پلاستیک World Journal of Plastic Surgery
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