WORLD JOURNAL OF PLASTIC SURGERY
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Volume 13, Issue 2 (2024)
WJPS 2024, 13(2): 50-57 |
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Mozafari N, Yavari M, Rouzbahani A K, Mozaffari M A, Mozafari A, Beiranvand S et al . Improved Neurotization in High Peripheral Nerve Injury: Side to Side H-shaped Nerve Graft at the Most Distal Part of an Injured Extremity in a Rabbit Model. WJPS 2024; 13 (2) :50-57
URL: http://wjps.ir/article-1-1294-en.html
URL: http://wjps.ir/article-1-1294-en.html
Naser Mozafari1 
, Masoud Yavari1 , Arian Karimi Rouzbahani2 , Mohammad Ali Mozaffari3 , Alireza Mozafari4 , Siavash Beiranvand5 , Hormoz Mahmoudvand * 6
, Masoud Yavari1 , Arian Karimi Rouzbahani2 , Mohammad Ali Mozaffari3 , Alireza Mozafari4 , Siavash Beiranvand5 , Hormoz Mahmoudvand * 6
1- Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
3- Corewell Health East, Dearborn, Michigan, USA.
4- Shahid Beheshti University, Daneshjoo Blvd, Tehran, Iran.
5- Department of Anesthesiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
6- Department of Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. ,dr.mahmoudvand@gmail.com
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
3- Corewell Health East, Dearborn, Michigan, USA.
4- Shahid Beheshti University, Daneshjoo Blvd, Tehran, Iran.
5- Department of Anesthesiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
6- Department of Surgery, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. ,
Abstract: (1378 Views)
Background: We aimed to investigate the effects of nerve repair by setting a side-to-side (H-shaped) nerve graft on the most distal part of the damaged nerve to the adjacent intact nerve to accelerate its regeneration in the end organ.
Methods: This pure experimental study was done on the lower extremities of two groups of rabbits in Animal Laboratory Department, 15 Khordad Hospital Tehran, Iran. In both groups, the sciatic nerve at the proximal part of the extremity below the superficial femoral branch was first cut and then repaired. In the investigation group, side-to-side H-shaped nerve grafts were applied between the sciatic and superficial femoral nerves (i.e., two branches) at the most distal to the cut site of the sciatic nerve below the superficial femoral branch at the lower extremity. The sciatic nerve was conventionally repaired in the control group.
Results: None of the rabbits’ feet in the control group respond to pain stimulation (were without senses) and had ulcers. They had numb legs and went lame. All had muscular atrophy and lacked nerve growth (regeneration) according to pathology. In the investigation group, 86.7% of the rabbits responded to pain stimulation and only 13.3% of them had ulcers. In addition, in pathology report, 13.3% had suffered muscular atrophy and lacked nerve regeneration. Therefore, nerve regeneration was successful in 86.7% of rabbits who underwent H-shaped nerve grafts.
Conclusion: Side-to-side H-shaped nerve graft at the most distal part of an injured nerve may cause successful recovery of high (proximal) nerve injury.
Methods: This pure experimental study was done on the lower extremities of two groups of rabbits in Animal Laboratory Department, 15 Khordad Hospital Tehran, Iran. In both groups, the sciatic nerve at the proximal part of the extremity below the superficial femoral branch was first cut and then repaired. In the investigation group, side-to-side H-shaped nerve grafts were applied between the sciatic and superficial femoral nerves (i.e., two branches) at the most distal to the cut site of the sciatic nerve below the superficial femoral branch at the lower extremity. The sciatic nerve was conventionally repaired in the control group.
Results: None of the rabbits’ feet in the control group respond to pain stimulation (were without senses) and had ulcers. They had numb legs and went lame. All had muscular atrophy and lacked nerve growth (regeneration) according to pathology. In the investigation group, 86.7% of the rabbits responded to pain stimulation and only 13.3% of them had ulcers. In addition, in pathology report, 13.3% had suffered muscular atrophy and lacked nerve regeneration. Therefore, nerve regeneration was successful in 86.7% of rabbits who underwent H-shaped nerve grafts.
Conclusion: Side-to-side H-shaped nerve graft at the most distal part of an injured nerve may cause successful recovery of high (proximal) nerve injury.
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