WORLD JOURNAL OF PLASTIC SURGERY
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Volume 13, Issue 3 (2024)
WJPS 2024, 13(3): 66-74 |
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Adibparsa M, Ghazavi M, Shetabi H. Impact of Topical Tranexamic Acid on Bleeding Control in Rhinoplasty. WJPS 2024; 13 (3) :66-74
URL: http://wjps.ir/article-1-1350-en.html
URL: http://wjps.ir/article-1-1350-en.html
1- Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran
3- Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ,hamidshetabi@med.mui.ac.ir
2- Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran
3- Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract: (221 Views)
Background: Hemorrhage during rhinoplasty may impair the surgeon's visibility.. Our objective was to examine the impact of subcutaneously administered Tranexamic acid (TXA) on bleeding during rhinoplasty.
Methods: A three-blind randomized clinical trial including 60 patients undergoing nose surgery was conducted to compare the effects of two different anesthetic solutions on surgery results. The control group received a solution consisting of 5 cc of 2% lidocaine and 0.5 cc of epinephrine, and the TXA group received a solution containing 5 ml of 2 lidocaine, 0.25 cc of epinephrine and 4.75 cc of 10% TXA. To achieve a total injection volume of 10 ml in both groups, distilled water was added. Bleeding rate, hemodynamic parameters, surgeon satisfaction and overall quality of the surgical field were evaluated.
Results: The hemodynamic parameters exhibited no notable differences between the two groups throughout the study period (P value > 0.05). The volume of bleeding observed in the TXA group was marginally greater than that in the control group (P value=0.061). Additionally, there were no significant variations in the quality of the surgical field or the satisfaction levels of the surgeon between the two groups.
Conclusion: In the TXA group, there was no increase in bleeding despite using a low concentration of epinephrine. Consequently, it is recommended that an injectable formulation of TXA containing a reduced concentration of epinephrine be used in surgical procedures where the use of high-concentration epinephrine is contraindicated, such as in patients with cardiovascular disease.
Methods: A three-blind randomized clinical trial including 60 patients undergoing nose surgery was conducted to compare the effects of two different anesthetic solutions on surgery results. The control group received a solution consisting of 5 cc of 2% lidocaine and 0.5 cc of epinephrine, and the TXA group received a solution containing 5 ml of 2 lidocaine, 0.25 cc of epinephrine and 4.75 cc of 10% TXA. To achieve a total injection volume of 10 ml in both groups, distilled water was added. Bleeding rate, hemodynamic parameters, surgeon satisfaction and overall quality of the surgical field were evaluated.
Results: The hemodynamic parameters exhibited no notable differences between the two groups throughout the study period (P value > 0.05). The volume of bleeding observed in the TXA group was marginally greater than that in the control group (P value=0.061). Additionally, there were no significant variations in the quality of the surgical field or the satisfaction levels of the surgeon between the two groups.
Conclusion: In the TXA group, there was no increase in bleeding despite using a low concentration of epinephrine. Consequently, it is recommended that an injectable formulation of TXA containing a reduced concentration of epinephrine be used in surgical procedures where the use of high-concentration epinephrine is contraindicated, such as in patients with cardiovascular disease.
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