WORLD JOURNAL OF PLASTIC SURGERY
Fri, Jan 3, 2025
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Volume 13, Issue 3 (2024)
WJPS 2024, 13(3): 57-65 |
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Hamedi Z S, Manafi A, Hashemi S, Mehrabani D, Seddighi A, Tanideh N et al . Healing Effect of Hypericum perforatum in Burn Injuries. WJPS 2024; 13 (3) :57-65
URL: http://wjps.ir/article-1-1351-en.html
URL: http://wjps.ir/article-1-1351-en.html
Zahra Sadat Hamedi1 
, Amir Manafi2 , Seyedeh-Sara Hashemi * 3, Davood Mehrabani4 , Anahita Seddighi5 , Nader Tanideh4 , Maral Mokhtari6
, Amir Manafi2 , Seyedeh-Sara Hashemi * 3, Davood Mehrabani4 , Anahita Seddighi5 , Nader Tanideh4 , Maral Mokhtari6
1- Division of Hematology, Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia
2- Department of Anesthesiology, Arrowhead Regional Medical Center, Colton, California
3- Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,sara_hashemi@sums.ac.ir
4- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5- Department of Molecular Biology, Universität Wien, Wien, Austria
6- Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Anesthesiology, Arrowhead Regional Medical Center, Colton, California
3- Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,
4- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5- Department of Molecular Biology, Universität Wien, Wien, Austria
6- Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (277 Views)
Background: Burn injury is still the leading cause of mortality and morbidity in burn patients. We comapred healing effect of Hypericum perforatum, silver sulfadiazine and alpha ointments on burn injuries in rat model.
Methods: Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as H. perforatum, silver sulfadiazine and (SSD), alpha, gel base and the burn injury left untreated. Wounds were assessed macroscopically and histologic after burn injury and on days 7th, 14th and 21st after treatments.
Results: Burn wounds decreased in size on day 7th in H. perforatum group (P<0.01). Regarding scoring the inflammation, re-epithelialization, angiogenesis, formation of granulation tissue and number of macrophage, the best scores were visible in H. perforatum group, and the worst in the gel base and the burn injury left untreated (P<0.01).
Conclusions: H. perforatum was shown to significantly induce re-epithelialization, angiogenesis and granulation tissue and decrease the inflammation resulting into a healing process in burn wounds. As H. perforatum is inexpensive and an easily available herbal medicine, it can be considered as a therapeutic of choice to ameliorate burn injuries.
Methods: Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as H. perforatum, silver sulfadiazine and (SSD), alpha, gel base and the burn injury left untreated. Wounds were assessed macroscopically and histologic after burn injury and on days 7th, 14th and 21st after treatments.
Results: Burn wounds decreased in size on day 7th in H. perforatum group (P<0.01). Regarding scoring the inflammation, re-epithelialization, angiogenesis, formation of granulation tissue and number of macrophage, the best scores were visible in H. perforatum group, and the worst in the gel base and the burn injury left untreated (P<0.01).
Conclusions: H. perforatum was shown to significantly induce re-epithelialization, angiogenesis and granulation tissue and decrease the inflammation resulting into a healing process in burn wounds. As H. perforatum is inexpensive and an easily available herbal medicine, it can be considered as a therapeutic of choice to ameliorate burn injuries.
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