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The Healing Effect of Plantago Major and Aloe Vera Mixture in Excisional Full Thickness Skin Wounds: Stereological Study
Soheil Ashkani-Esfahani , Mahsima Khoshneviszadeh , Ali Noorafshan , Ramin Miri , Shima Rafiee , Kimia Hemyari , Sina Kardeh , Omid Koohi Hosseinabadi , Dorna Fani , Elnaz Faridi
Abstract:   (186 Views)
BACKGROUND
Previous studies indicated that both Plantago major and Aloe vera have anti-inflammatory, tissue regeneration, antioxidant, and immune-stimulatory effects. It is assumed that a mixture of these two herbal medicines may provide a potent material in treatment of skin wound injuries. Therefore, in this study we investigated the effects of Plantago major and Aloe vera mixture in the process of wound healing in rat models according to stereological parameters.
METHODS
In an experiential study, 36 male Sprague-Dawley rats (200±20 g) were randomly assigned into three groups (n=12): The control group which received no treatment, gel base treated group, and the 5% Plantago major and 5% Aloe vera mixture gel treated group (PA group). Treatments were done every 24 hrs for 15 days. Wound closure rate, volume densities of the collagen bundles and the vessels, vessel’s length density and mean diameter, and fibroblast populations were estimated using stereological methods.
RESULTS
PA treated group showed faster wound closure rate in comparison with control and gel-base groups (p<0.05). Numerical density of fibroblasts, volume density of collagen bundles, mean diameter, and volume densities of the vessels in PA group were significantly higher than the control and the gel-base treated groups (p<0.05).
CONCLUSION
We showed that Plantago major and Aloe vera mixture has the ability to improve wound healing by enhancing fibroblast proliferation, collagen bundle synthesis and re-vascularization in skin injuries.
Keywords: Wound healing, Fibroblast, Collagen, Vascularization, Plantago major, Aloevera, Stereology, Rat
Full-Text [PDF 2473 kb]   (73 Downloads)    
Type of Study: Original Article | Subject: General
Received: 2015/09/8
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مجله جهانی جراحی پلاستیک World Journal of Plastic Surgery
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