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The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas
Adil Ali , Umme Aiman , Mohd Azam Haseen , Mohd Altaf Mir , Imran Ghani , Ragya Bharadwaj , Mohd. Yaseen
JNMCH, AMU,Aligarh
Abstract:   (37 Views)

Haemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol when compared to oral steroids in management of pediatric haemangiomas.
In North India from January 2012 to January 2015, sixty children <6 years old with superficial haemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks. The Haemangioma Activity Score (HAS) was used for scoring and patients were followed up for 6 months.
The propranolol group mostly showed early response to the drug and needed the drug for less time compared to corticosteroid group. In propranolol group, 16.5%, 23% and 59% needed the drug to be continued for 8-12, 4-8 and 4 months. In corticosteroid group, the therapy was continued for 8-12, and 4-8 months in 76.8% and 16.5% and in 6.6% was stopped within 4 months. In propranolol group, the response was 70% compared to 40% in other group. The mean HAS decreased significantly in propranolol group when compared to steroid group. Three patients on prednisolone developed Cushingoid features, while 1 patient in propranolol group had mild flue like symptoms.
Two mg/kg of oral propranolol significantly decreased HAS, when compared to oral prednisolone, with good parent satisfaction, minimal adverse effects and no recurrence/relapse of haemangiomas after a follow up period of 6 months.

Keywords: Pediatric haemangiomas, Propranolol, Corticosteroids
Full-Text [PDF 3849 kb]   (15 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2016/09/4 | Accepted: 2017/09/1 | Published: 2018/01/11
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Ali A, Aiman U, Haseen M A, Mir M A, Ghani I, Bharadwaj R et al . The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas. wjps. 2018; 7 (1)
URL: http://wjps.ir/article-1-280-en.html
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