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The Healing Effect of N-Hexan- Dichloromethane Extract Root Onosma Bulbotrichum in Second Degree Burns
Aliasghar Hemmati , Forough Namjuyan , Sadegh Yousefi , Gholamreza Housmand , Hossein Khadem Haghighian , Anahita Rezaei
Department of Pharmacology. Toxicology, School of Pharmacy, Physiology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (179 Views)

BACKGROUND
Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root Onosma bulbotrichum DC on the second degree burn in rabbit model was investigated.
METHODS
Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% O. bulbotrichum cream and assessed histologically.
RESULTS
The best result was shown in 5% O. bulbotrichum group similar to silver sulfadiazine group. The maximum amount of collagen and the tensile strength of tissue were observed in 5% O. bulbotrichum and silver sulfadiazine groups. Histopathological examination showed that burn healing in treatment group with 5% O. bulbotrichum was faster than other groups.
CONCLUSION
The 5% O. bulbotrichum cream was shown to have healing, and anti-inflammatory effects when used in treatment of second degree burns.

Keywords: Burn, Healing, Silver sulfadiazine, Onosma bulbotrichum, Rabbit
Full-Text [PDF 2166 kb]   (52 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2016/09/10 | Accepted: 2017/08/29 | Published: 2018/01/13
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Hemmati A, Namjuyan F, Yousefi S, Housmand G, Khadem Haghighian H, Rezaei A. The Healing Effect of N-Hexan- Dichloromethane Extract Root Onosma Bulbotrichum in Second Degree Burns. wjps. 2018; 7 (1)
URL: http://wjps.ir/article-1-281-en.html


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