WORLD JOURNAL OF PLASTIC SURGERY
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Volume 7, Issue 1 (2018)
WJPS 2018, 7(1): 3-11 |
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Khodakaram-Tafti A, Mehrabani D, Shaterzadeh-Yazdi H, Zamiri B, Omidi M. Tissue Engineering in Maxillary Bone Defects. WJPS 2018; 7 (1) :3-11
URL: http://wjps.ir/article-1-357-en.html
URL: http://wjps.ir/article-1-357-en.html
Azizollah Khodakaram-Tafti1 
, Davood Mehrabani * 2, Hanieh Shaterzadeh-Yazdi1 , Barbad Zamiri3 , Mahsa Omidi4
, Davood Mehrabani * 2, Hanieh Shaterzadeh-Yazdi1 , Barbad Zamiri3 , Mahsa Omidi4
1- Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,mehrabanittrc@gmail.com
3- Department of Craniomaxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ,
3- Department of Craniomaxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (5195 Views)
BACKGROUND
Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit.
METHODS
Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest. After 4 and 8 weeks, five rabbits from each group were sacrificed and the defects were evaluated morphologically, by coronal computed tomography scanning (CT-scan) and by histological examinations.
RESULTS
The healing effect of fibrin glue scaffold and autologous bone graft was similar with appropriate osteogenesis in comparison to the control group.
CONCLUSION
Using fibrin glue can be a non-invasive treatment of choice in mandibular defects and maxillofacial surgeries when compared with autologous bone graft.
Restoration of craniofacial bone defects has been a concern for oral and maxillofacial surgeons. In this study, the healing effect of fibrin glue scaffold was compared with autologous bone graft in mandibular defects of rabbit.
METHODS
Bilateral unicortical osteotomy was performed in the diastema region of 10 male Dutch rabbits. The subjects were randomly divided into 2 equal groups. The mandibular defect on the right side was treated with fibrin glue scaffold and the defect on the left side with autologous bone graft provided from iliac crest. After 4 and 8 weeks, five rabbits from each group were sacrificed and the defects were evaluated morphologically, by coronal computed tomography scanning (CT-scan) and by histological examinations.
RESULTS
The healing effect of fibrin glue scaffold and autologous bone graft was similar with appropriate osteogenesis in comparison to the control group.
CONCLUSION
Using fibrin glue can be a non-invasive treatment of choice in mandibular defects and maxillofacial surgeries when compared with autologous bone graft.
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