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Candida Antigen Titer Elevation and Mortality in Burn Patients
Sebastian Jachec , Walter Perbix , Paul-Christian Fuchs , Rolf Lefering , Christian Weinand
Helios Klinikum Gifhorn, Klinik für Plastische, Rekonstruktive und Ästhetische Medizin, Handchirurgie, Verbrennungen, Universität Witten-Herdecke
Abstract:   (456 Views)
Mortality in burn patients has several contributing factors as sex, age, degree of burns, or inhalation injuries. Usefulness of Candida antigen (CAG) titer is still being under debate to predict mortality. This study assessed correlation between CAG titer and mortality in burn patients.
From 1988 to 2011, 877 burn intensive care patients were evaluated for age, sex, total burn surface area (TBSA), multi organ failure (MOF), burn depth, escharotomy, fasciotomy, antibiotic use, co-morbidities, CAG titer and intubation. 
From 870 admitted patients, 190 patients were not enrolled. Increasing age was correlated with a higher mortality. The ABSI score of the deceased was 4 points and the TBSA was 20% higher than the survivors. The correlation for age, intubation, TBSA, inhalation injury, MOF, CAG titer, antibiotic use and escharotomy was significant. An increasing mortality was noted with antibiotic use and a CAG titer of 1:8 and higher. CAG titer of 1:8 and higher had a sensitivity of 51.1% and specificity of 86.3% for mortality. Multivariate analysis confirmed high influence of older age, MOF, comorbidities, antibiotic use and CAG titer of 1:8 and higher on mortality. There was a significant correlation for sex, younger age and CAG titer.
CAG titers of 1:8 and higher might warrant beginning of antimycotic treatment in elderly patients with high TBSA to avoid increase in mortality.
Keywords: Candida, Burn, Mortality, CAG titer
Full-Text [PDF 308 kb]   (806 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2018/06/10
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