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Montelukast for Medical Delay in Flap Surgery
Maryam Iranpour, Ali Khodarahmi , Nima Khodarahmi, Mohammad Shafiee, Reza Malekpourafshar, Nozar Nakhaee
Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (338 Views)
Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.
In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8×3 cm rectangular randomized random skin flap was first surgically delayed at rats’ back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14th days, the photos were taken and the size of the necrotic area of the flap was measured.
A significant difference was observed between the mean survival and angiogenesis (p=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (p>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (p<0.05). Finally, the inflammation showed no significant difference (p>0.05).
Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies.
Keywords: Flaps, Medical delay, Montelukast
Full-Text [PDF 1242 kb]   (95 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2019/07/1
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مجله جهانی جراحی پلاستیک World Journal of Plastic Surgery
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