Volume 11, Issue 1 (3-2022)                   WJPS 2022, 11(1): 30-37 | Back to browse issues page

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Iranpour M, Khodarahmi A, Beigi M, Azari O, Shahraki S S. Effects of Botulinum Toxin Type A on the Axial Skin Flap Survival. WJPS. 2022; 11 (1) :30-37
URL: http://wjps.ir/article-1-898-en.html
2. Department of Surgery, Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (801 Views)
A suitable pharmacological substitute for the well-established surgical delay technique for axial skin flaps regarding increasing viability is elusive. We aimed to evaluate the effects of botulinum toxin type A (BTA) on the axial skin flap survival in a rat model.
The present controlled experimental study was performed in Kerman University of Medical Science, Kermanshah, Iran during 2016-2017 on three groups of rats. Group 1 (control group) had no preconditioning while Groups 2 and 3 were preconditioned by the intradermal injection of normal saline (0.5 ml) in the cephalic end of the skin flap and the injection of the BTA (1.6 units Neuronex) reconstituted in normal saline, respectively. Two weeks after this intervention in each group, the flap was raised and kept in situ and a biopsy was simultaneously taken for evaluating neoangiogenesis, followed by evaluating flap necrosis after two weeks of following-up by photography.
Although BTA induced angiogenesis significantly, it failed to reduce the area of necrosis compared to the other groups.
BTA was effective in increasing angiogenesis in the axial skin flap although it was unable to reduce necrosis.
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Type of Study: Original Article | Subject: Special
Received: 2022/02/23 | Accepted: 2021/10/26 | Published: 2022/03/4

1. Cristina PC, Alfredo LJ, Cláudia NB, Miriam L, et al. Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats. Acta Cirúrgica Brasileira 2015; Vol. 30 (9): 639 – 645. 2. Ghanbarzadeh K, Tabatabaie OR, Salehifar E, Amanlou M, et al. Effect of botulinum toxin A and nitroglycerin on random skin flap survival in rats. Plast Surg 2016; 24 9(2): 99-102. 3. Hikmet K, Burak K, Muzaffer C, Ahmet T, Gürcan A. Prevention of unfavourable effects of cigarette smoke on flap viability using botulinum toxin in random pattern flaps: An experimental study. Plast Surg 2015; 23 (3):177-182. 4. Iranpour M, Khodarahmi A, Khodarahmi N, Shafiee M, et al. Montelukast for Medical Delay in Flap Surgery. World J Plast Surg 2020; 9 (1): 48-54. 5. Akihiko U, Kazuya Y, Buddhini P, Sachiko O, et al. Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury. Scientific Reports 2015;5:9072. doi: 10.1038/srep09072: 1-7. 6. Peter BA, Taolin F, Somjade JS, Georgios Z, et al. Inflammatory Response and Survival of Pedicled Abdominal Flaps in a Rat Model after Perivascular Application of Botulinum Toxin Type A. Plast Reconstr Surg 2014: 133(4):491e-498e. 7. Alfred G, Johanna K, Melanie S, Elisabeth B, et al. Botulinum Toxin A: Dose-dependent Effect on Reepithelialization and Angiogenesis. Plast Reconstr Surg Glob Open 2016;4:e837: 1-7. 8. Tai S, Bok KJ, Insik Y, Dae HL, et al. Effect of botulinum toxin A on vasoconstriction and sympathetic neurotransmitters in a murine random pattern skin flap model. Wound Repair Regen 2016; 20 25(1):75-85. 9. Tae HP, Song HL, Yun J, Young SL, et al. Presurgical Botulinum Toxin A Treatment Increases Angiogenesis by Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor and Subsequent Superiorly Based Transverse Rectus Abdominis Myocutaneous Flap Survival in a Rat Model. Ann Plast Surg 2016;76: 723–728. 10. Yun JP, Jang WL, Yosep Ch,Tae HP. Botulinum toxin A increases allograft tolerance in an experimental transplantation model: a preliminary study. Bioscience Reports 2018; 38 BSR20171721: 1-8. 11. Tae HP, Ji H, Choong HC, Dong KR. Botulinum Toxin A Upregulates Rac1, Cdc42, and RhoA Gene Expression in a Dose-Dependent Manner: In Vivo and in Vitro Study. J Craniofac Surg 2016;27: 516–520. 12. Yanyu S, Huang L., Jiankun C, Chao C. Botulinum toxin type A induces protective autophagy in human dermal microvascular endothelial cells exposed to an in vitro model of ischemia/reperfusion injury. Exp Ther Med 2018; 16: 4379-4386. 13. Roberto GA, Somjade JS, Samantha RS, Peter BA, et al. Microcirculatory Effects of Botulinum Toxin A in the Rat Acute and Chronic Vasodilation. Ann Plast Surg 2017;79: 82–85. 14. Tae HP, Yun JP. The Effect of Botulinum Toxin A on Ischemia-Reperfusion Injury in a Rat Model. Biomed Res Int 2017;2017:1074178. 15. Huang L. Beneficial effect of botulinum toxin A on secondary ischaemic injury of skin flaps in rats. Br J Oral Maxillofac Surg 2018; 56: 144-147. 16. Miao C, Xiucun L, Zhenmin J, Xu G. Visualizing the Pharmacologic Preconditioning Effect of Botulinum Toxin Type A by Infrared Thermography in a Rat Pedicled Perforator Island Flap Model . Plast Reconstr Surg 2019; 144: 1016e. 17. Umut Z, Neşe KÖ, Zekiye H. Effect of Botulinum Toxin-A Injected to Muscle Tissue on Perfusion and Survival of Fasciocutaneous Single Perforator-pedicled Propeller Flap in Rats. Balkan Med J 2020;37:84-90. 18. Wael M El S, Ahmed EEA, Wael MS, Emad MH, et al. Effect of Perivascular Injection of Botulinum Toxin Type A versus Lidocaine in Survival of Random Pattern Flaps in a Rat Model. Plast. Reconstr Surg 2019; 143: 527e. 19. Sung YK, Song HL, Boram L, Yun JP, et al. The Protective Effects of Botulinum Toxin A Against Flap Necrosis After Perforator Twisting and Its Underlying Molecular Mechanism in a Rat Model. Ann Plast Surg 2016;77: 242–248. 20. Cristina PC, Felipe AF, Michel HML, Luiza CMS, et al. The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats. Acta Cirúrgica Brasileira 2016; Vol. 31 (11): 720- 723. 21. Go¨khan T, Nebil Y, Hakan S, Ali CA, et al. Increasing the survival of transverse rectus abdominis musculocutaneous flaps with a Botulinum toxin-A injection: A comparison of surgical and chemical flap delay methods. J Plast Reconstr Aesthet Surg 2016; 69, 944-951. 22. Tae HP, Dong KR, Yosep C, June-kyu K. The Effects of Botulinum Toxin A on Survival of Rat TRAM Flap With Vertical Midline Scar. Ann Plast Surg 2015;74: 100-106.

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