WORLD JOURNAL OF PLASTIC SURGERY
Fri, Apr 26, 2024
[Archive]
Volume 9, Issue 1 (2020)
WJPS 2020, 9(1): 48-54 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Iranpour M, Khodarahmi A, Khodarahmi N, Shafiee M, Malekpourafshar R, Nakhaee N. Montelukast for Medical Delay in Flap Surgery. WJPS 2020; 9 (1) :48-54
URL: http://wjps.ir/article-1-524-en.html
URL: http://wjps.ir/article-1-524-en.html
Maryam Iranpour1 
, Ali Khodarahmi 2, Nima Khodarahmi3 , Mohammad Shafiee4 , Reza Malekpourafshar1 , Nozar Nakhaee5
, Ali Khodarahmi 2, Nima Khodarahmi3 , Mohammad Shafiee4 , Reza Malekpourafshar1 , Nozar Nakhaee5
1- Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran , khodarahmiali@yahoo.com
3- Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
4- Assistant Professor of Surgery HPB and Transplant Surgeon, Afzalipoor Hospital , Kerman
5- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran , khodarahmiali@yahoo.com
3- Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
4- Assistant Professor of Surgery HPB and Transplant Surgeon, Afzalipoor Hospital , Kerman
5- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract: (3792 Views)
BACKGROUND
Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.
METHODS
In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8×3 cm rectangular randomized random skin flap was first surgically delayed at rats’ back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14th days, the photos were taken and the size of the necrotic area of the flap was measured.
RESULTS
A significant difference was observed between the mean survival and angiogenesis (p=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (p>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (p<0.05). Finally, the inflammation showed no significant difference (p>0.05).
CONCLUSION
Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies.
Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.
METHODS
In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8×3 cm rectangular randomized random skin flap was first surgically delayed at rats’ back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14th days, the photos were taken and the size of the necrotic area of the flap was measured.
RESULTS
A significant difference was observed between the mean survival and angiogenesis (p=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (p>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (p<0.05). Finally, the inflammation showed no significant difference (p>0.05).
CONCLUSION
Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
