Volume 9, Issue 1 (1-2020)                   WJPS 2020, 9(1): 44-47 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Akbari H, Farrokhi B, Emami S, Akhoondinasab M, Akbari P, Karimi H. Comparison of the Never Repair with Fibrin Glue and Perineural Micro-Suture in Rat Model. WJPS. 2020; 9 (1) :44-47
URL: http://wjps.ir/article-1-491-en.html
Department of Plastic and Reconstructive Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; , : hakbari1339@yahoo.com
Abstract:   (2527 Views)
Many different methods for nerve repair have been introduced. Nerve repair with micro-suture is the gold standard one; however, the use of fibrin glue is a promising method. This study compared the never repair with fibrin glue and perineural micro-suture in rat model.
Ten 3-4 month old male rats, weighting between 250-300 grams were divided into two groups. Left sciatic nerves of the rats were transected and repaired with fibrin glue (TissucolR) in one group (A) and direct peri-neural micro-suture in another group (B). The time of nerve repair was compared between the two groups after 8 weeks. A biopsy from was taken from anastomosis site and the histopathological assessment was undertaken for axonal growth rate after anastomosis and compared between the two groups.
The time of repair in group A was significantly lower than group B. Axonal growth rate was pretty similar between the two groups, and the difference was not significant. The mean (SD) time for repair of nerves with micro-sutures was 7.1 (1.5) minutes and the mean (SD) for repair of nerves with fibrin glue was 2.5 (0.5) minutes and the difference was significant. The number of calcification such as psammoma bodies was significantly higher in fibrin glue group. 
Nerve repair with fibrin glue was shown to be simpler and more time saving. The number of axons after the repair was not different in the two groups. We showed that fibrin glue may have more tissue reactions compared with micro-sutures.
Full-Text [PDF 1170 kb]   (1437 Downloads)    
Type of Study: Original Article | Subject: Special
Received: 2019/03/24 | Accepted: 2020/01/31 | Published: 2020/01/31

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | World Journal of Plastic Surgery

Designed & Developed by : Yektaweb