WORLD JOURNAL OF PLASTIC SURGERY
Tue, Apr 16, 2024
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Volume 9, Issue 1 (2020)
WJPS 2020, 9(1): 44-47 |
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Akbari H, Farrokhi B, Emami S, Akhoondinasab M, Akbari P, Karimi H. Comparison of the Never Repair with Fibrin Glue and Perineural Micro-Suture in Rat Model. WJPS 2020; 9 (1) :44-47
URL: http://wjps.ir/article-1-491-en.html
URL: http://wjps.ir/article-1-491-en.html
Hossein Akbari1 
, Behzad Farrokhi 2, Seyed-Abolhassan Emami1 , Mohammad-Reza Akhoondinasab1 , Peyman Akbari3 , Hamid Karimi1
, Behzad Farrokhi 2, Seyed-Abolhassan Emami1 , Mohammad-Reza Akhoondinasab1 , Peyman Akbari3 , Hamid Karimi1
1- Department of Plastic and Reconstructive Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;
2- Department of Plastic and Reconstructive Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; , : hakbari1339@yahoo.com
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Plastic and Reconstructive Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; , : hakbari1339@yahoo.com
3- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (3182 Views)
BACKGROUND
Many different methods for nerve repair have been introduced. Nerve repair with micro-suture is the gold standard one; however, the use of fibrin glue is a promising method. This study compared the never repair with fibrin glue and perineural micro-suture in rat model.
METHODS
Ten 3-4 month old male rats, weighting between 250-300 grams were divided into two groups. Left sciatic nerves of the rats were transected and repaired with fibrin glue (TissucolR) in one group (A) and direct peri-neural micro-suture in another group (B). The time of nerve repair was compared between the two groups after 8 weeks. A biopsy from was taken from anastomosis site and the histopathological assessment was undertaken for axonal growth rate after anastomosis and compared between the two groups.
RESULTS
The time of repair in group A was significantly lower than group B. Axonal growth rate was pretty similar between the two groups, and the difference was not significant. The mean (SD) time for repair of nerves with micro-sutures was 7.1 (1.5) minutes and the mean (SD) for repair of nerves with fibrin glue was 2.5 (0.5) minutes and the difference was significant. The number of calcification such as psammoma bodies was significantly higher in fibrin glue group.
CONCLUSION
Nerve repair with fibrin glue was shown to be simpler and more time saving. The number of axons after the repair was not different in the two groups. We showed that fibrin glue may have more tissue reactions compared with micro-sutures.
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