WORLD JOURNAL OF PLASTIC SURGERY
Tue, Apr 16, 2024
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Volume 11, Issue 1 (2022)
WJPS 2022, 11(1): 117-124 |
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Erdi A M, Arabzadeh A, IssazadehFar K, Masoumzadeh M, Bahadoram M. Comparing the Efficacy and Side Effects of Intravenous Ibuprofen and Acetaminophen in Pain Control Following Laparoscopic Cholecystectomy. WJPS 2022; 11 (1) :117-124
URL: http://wjps.ir/article-1-888-en.html
URL: http://wjps.ir/article-1-888-en.html
Ali Mohammadian Erdi1 
, AmirAhmad Arabzadeh 2, Khatereh IssazadehFar3 , Mahdieh Masoumzadeh4 , Mohammad Bahadoram5
, AmirAhmad Arabzadeh 2, Khatereh IssazadehFar3 , Mahdieh Masoumzadeh4 , Mohammad Bahadoram5
1- Department of Anesthesiology and Pain Management, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2- Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3- Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
4- School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
5- Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3- Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
4- School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
5- Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract: (2381 Views)
BACKGROUND
The importance of using effective postoperative analgesia is widely accepted. Systemic opioids are the gold standard for reducing severe pain after surgery, but the side effects have limited the use of adequate doses. We aimed to evaluate the effect of adding intravenous acetaminophen and intravenous ibuprofen to fentanyl on patient-controlled analgesia.
METHODS
In this randomized clinical trial study in Ardabil city hospital at 2019, 90 patients undergoing elective laparoscopic cholecystectomy were randomly divided into three groups. The control group (n=30) received normal saline, the acetaminophen group (n=30) received 1g intravenous acetaminophen, and the ibuprofen group (n=30) received 800 mg intravenous ibuprofen. All patients received a pain control by intravenous pump containing fentanyl (15µ/ml). The drugs were injected intravenously after surgery. Shoulder and abdominal pain scores, sedation rate, nausea and vomiting, satisfaction, and the doses of fentanyl and meperidine were recorded in SPSS software within 24 h after surgery.
RESULTS
The mean abdominal pain scores in ibuprofen (3.02) and acetaminophen (2.89) groups were not significantly different (P=0.719) but were significantly lower than in the control group (5.10) (P<0.001). The severity of shoulder pain, nausea and vomiting, sedation, and fentanyl intake were not significantly different in the ibuprofen and acetaminophen groups but were significantly lower than in the control group.
CONCLUSION
The use of both intravenous acetaminophen and ibuprofen in pain control after surgery can reduce the need for opioid use. Acetaminophen can also be a suitable alternative for postoperative pain control in patients that are unable to use NSAIDs.
The importance of using effective postoperative analgesia is widely accepted. Systemic opioids are the gold standard for reducing severe pain after surgery, but the side effects have limited the use of adequate doses. We aimed to evaluate the effect of adding intravenous acetaminophen and intravenous ibuprofen to fentanyl on patient-controlled analgesia.
METHODS
In this randomized clinical trial study in Ardabil city hospital at 2019, 90 patients undergoing elective laparoscopic cholecystectomy were randomly divided into three groups. The control group (n=30) received normal saline, the acetaminophen group (n=30) received 1g intravenous acetaminophen, and the ibuprofen group (n=30) received 800 mg intravenous ibuprofen. All patients received a pain control by intravenous pump containing fentanyl (15µ/ml). The drugs were injected intravenously after surgery. Shoulder and abdominal pain scores, sedation rate, nausea and vomiting, satisfaction, and the doses of fentanyl and meperidine were recorded in SPSS software within 24 h after surgery.
RESULTS
The mean abdominal pain scores in ibuprofen (3.02) and acetaminophen (2.89) groups were not significantly different (P=0.719) but were significantly lower than in the control group (5.10) (P<0.001). The severity of shoulder pain, nausea and vomiting, sedation, and fentanyl intake were not significantly different in the ibuprofen and acetaminophen groups but were significantly lower than in the control group.
CONCLUSION
The use of both intravenous acetaminophen and ibuprofen in pain control after surgery can reduce the need for opioid use. Acetaminophen can also be a suitable alternative for postoperative pain control in patients that are unable to use NSAIDs.
Keywords: Intravenous ibuprofen, Intravenous acetaminophen, Postoperative pain control, Cholecystectomy
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